Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.
Identifieur interne : 000A65 ( Main/Exploration ); précédent : 000A64; suivant : 000A66Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.
Auteurs : Teluguakula Narasaraju [États-Unis] ; Benjamin M. Tang [Australie] ; Martin Herrmann [Allemagne] ; Sylviane Muller [France] ; Vincent T K. Chow [Singapour] ; Marko Radic [États-Unis]Source :
- Frontiers in pharmacology [ 1663-9812 ] ; 2020.
Abstract
There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. Many patients, who recover, experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release. Moreover, we suggest that currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19. In our view, targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.
DOI: 10.3389/fphar.2020.00870
PubMed: 32581816
PubMed Central: PMC7291833
Affiliations:
- Allemagne, Australie, France, Singapour, États-Unis
- Alsace (région administrative), Bavière, District de Moyenne-Franconie, Grand Est, Oklahoma, Tennessee
- Erlangen, Strasbourg
- Université nationale de Singapour
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.</title><author><name sortKey="Narasaraju, Teluguakula" sort="Narasaraju, Teluguakula" uniqKey="Narasaraju T" first="Teluguakula" last="Narasaraju">Teluguakula Narasaraju</name><affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Veterinary Medicine, Oklahoma State University, Stillwater, OK</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Tang, Benjamin M" sort="Tang, Benjamin M" uniqKey="Tang B" first="Benjamin M" last="Tang">Benjamin M. Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Medicine, Nepean Hospital, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Intensive Care Medicine, Nepean Hospital, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Muller, Sylviane" sort="Muller, Sylviane" uniqKey="Muller S" first="Sylviane" last="Muller">Sylviane Muller</name><affiliation wicri:level="1"><nlm:affiliation>CNRS-University of Strasbourg, Biotechnology and Cell Signaling, Illkirch, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS-University of Strasbourg, Biotechnology and Cell Signaling, Illkirch</wicri:regionArea><wicri:noRegion>Illkirch</wicri:noRegion><wicri:noRegion>Illkirch</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Excellence Medalis, Institut de science et d'ingénierie supramoléculaire, and University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Excellence Medalis, Institut de science et d'ingénierie supramoléculaire, and University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Infectious Diseases Program, School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology and Immunology, Infectious Diseases Program, School of Medicine, National University of Singapore, National University Health System, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Radic, Marko" sort="Radic, Marko" uniqKey="Radic M" first="Marko" last="Radic">Marko Radic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Immunology and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32581816</idno><idno type="pmid">32581816</idno><idno type="doi">10.3389/fphar.2020.00870</idno><idno type="pmc">PMC7291833</idno><idno type="wicri:Area/Main/Corpus">000C21</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C21</idno><idno type="wicri:Area/Main/Curation">000C21</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000C21</idno><idno type="wicri:Area/Main/Exploration">000C21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.</title><author><name sortKey="Narasaraju, Teluguakula" sort="Narasaraju, Teluguakula" uniqKey="Narasaraju T" first="Teluguakula" last="Narasaraju">Teluguakula Narasaraju</name><affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Veterinary Medicine, Oklahoma State University, Stillwater, OK</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Tang, Benjamin M" sort="Tang, Benjamin M" uniqKey="Tang B" first="Benjamin M" last="Tang">Benjamin M. Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Medicine, Nepean Hospital, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Intensive Care Medicine, Nepean Hospital, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Muller, Sylviane" sort="Muller, Sylviane" uniqKey="Muller S" first="Sylviane" last="Muller">Sylviane Muller</name><affiliation wicri:level="1"><nlm:affiliation>CNRS-University of Strasbourg, Biotechnology and Cell Signaling, Illkirch, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS-University of Strasbourg, Biotechnology and Cell Signaling, Illkirch</wicri:regionArea><wicri:noRegion>Illkirch</wicri:noRegion><wicri:noRegion>Illkirch</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Excellence Medalis, Institut de science et d'ingénierie supramoléculaire, and University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Excellence Medalis, Institut de science et d'ingénierie supramoléculaire, and University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Infectious Diseases Program, School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology and Immunology, Infectious Diseases Program, School of Medicine, National University of Singapore, National University Health System, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Radic, Marko" sort="Radic, Marko" uniqKey="Radic M" first="Marko" last="Radic">Marko Radic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Immunology and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Immunology and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Frontiers in pharmacology</title><idno type="ISSN">1663-9812</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. Many patients, who recover, experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release. Moreover, we suggest that currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19. In our view, targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32581816</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>27</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1663-9812</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in pharmacology</Title><ISOAbbreviation>Front Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.</ArticleTitle><Pagination><MedlinePgn>870</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fphar.2020.00870</ELocationID><Abstract><AbstractText>There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. Many patients, who recover, experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release. Moreover, we suggest that currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19. In our view, targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.</AbstractText><CopyrightInformation>Copyright © 2020 Narasaraju, Tang, Herrmann, Muller, Chow and Radic.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Narasaraju</LastName><ForeName>Teluguakula</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Benjamin M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Medicine, Nepean Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrmann</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>Sylviane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CNRS-University of Strasbourg, Biotechnology and Cell Signaling, Illkirch, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Excellence Medalis, Institut de science et d'ingénierie supramoléculaire, and University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Vincent T K</ForeName><Initials>VTK</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Infectious Diseases Program, School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radic</LastName><ForeName>Marko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P20 GM103648</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Pharmacol</MedlineTA><NlmUniqueID>101548923</NlmUniqueID><ISSNLinking>1663-9812</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">acute respiratory distress syndrome</Keyword><Keyword MajorTopicYN="N">neutrophil extracellular traps</Keyword><Keyword MajorTopicYN="N">neutrophilia</Keyword><Keyword MajorTopicYN="N">neutrophils</Keyword><Keyword MajorTopicYN="N">pathogenesis</Keyword><Keyword MajorTopicYN="N">therapeutics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32581816</ArticleId><ArticleId IdType="doi">10.3389/fphar.2020.00870</ArticleId><ArticleId IdType="pmc">PMC7291833</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Commun. 2019 Jul 31;10(1):3422</Citation><ArticleIdList><ArticleId IdType="pubmed">31366921</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Microbes Infect. 2020 Dec;9(1):761-770</Citation><ArticleIdList><ArticleId IdType="pubmed">32228226</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood Adv. 2018 Apr 10;2(7):731-744</Citation><ArticleIdList><ArticleId IdType="pubmed">29592875</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2013 Jan 15;187(2):160-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23220920</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jul 16;290(3):374-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12865379</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2018 Jan 8;18(1):23</Citation><ArticleIdList><ArticleId IdType="pubmed">29310581</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2018 Jan;188(1):135-148</Citation><ArticleIdList><ArticleId IdType="pubmed">29107075</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Rheum Dis. 2013 Nov;72(11):1830-5</Citation><ArticleIdList><ArticleId IdType="pubmed">23172751</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Clin Pathol. 2020 May 5;153(6):725-733</Citation><ArticleIdList><ArticleId IdType="pubmed">32275742</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2011 Jul;179(1):199-210</Citation><ArticleIdList><ArticleId IdType="pubmed">21703402</ArticleId></ArticleIdList></Reference><Reference><Citation>Open Forum Infect Dis. 2019 Apr 03;6(4):ofz163</Citation><ArticleIdList><ArticleId IdType="pubmed">31041358</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2018 Dec 27;22(1):358</Citation><ArticleIdList><ArticleId IdType="pubmed">30587204</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2018 Sep 18;9:2036</Citation><ArticleIdList><ArticleId IdType="pubmed">30279690</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2008 Feb 1;180(3):1895-902</Citation><ArticleIdList><ArticleId IdType="pubmed">18209087</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Apr;8(4):420-422</Citation><ArticleIdList><ArticleId IdType="pubmed">32085846</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2019 Feb 05;10:47</Citation><ArticleIdList><ArticleId IdType="pubmed">30804927</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2018 Nov 1;128(11):5178-5183</Citation><ArticleIdList><ArticleId IdType="pubmed">30204591</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Clin Pharmacol. 2015 Dec;80(6):1324-36</Citation><ArticleIdList><ArticleId IdType="pubmed">26182832</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation><ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2017 Dec 1;358(6367):1202-1206</Citation><ArticleIdList><ArticleId IdType="pubmed">29191910</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2012 Mar 1;188(5):2419-26</Citation><ArticleIdList><ArticleId IdType="pubmed">22266279</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2018 Apr 11;10(436):</Citation><ArticleIdList><ArticleId IdType="pubmed">29643232</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation><ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId></ArticleIdList></Reference><Reference><Citation>Autophagy. 2015;11(3):472-86</Citation><ArticleIdList><ArticleId IdType="pubmed">25719862</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Pulm Dis. 2016 Oct;2(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">27981251</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2014 Dec;12(12):2074-88</Citation><ArticleIdList><ArticleId IdType="pubmed">25163512</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Immunol. 2007 Aug;28(8):340-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17627888</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Apr;92(4):401-402</Citation><ArticleIdList><ArticleId IdType="pubmed">31950516</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 Apr;80(4):388-393</Citation><ArticleIdList><ArticleId IdType="pubmed">32112884</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Pathol. 2006 Apr;37(4):381-90</Citation><ArticleIdList><ArticleId IdType="pubmed">16564911</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2018 Sep 26;9:2158</Citation><ArticleIdList><ArticleId IdType="pubmed">30319621</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2017 Jul 28;8:874</Citation><ArticleIdList><ArticleId IdType="pubmed">28804484</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Intern Med. 2020 Mar 13;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32167524</ArticleId></ArticleIdList></Reference><Reference><Citation>J Korean Med Sci. 2016 Nov;31(11):1717-1725</Citation><ArticleIdList><ArticleId IdType="pubmed">27709848</ArticleId></ArticleIdList></Reference><Reference><Citation>Biosci Trends. 2020 Apr 22;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32321904</ArticleId></ArticleIdList></Reference><Reference><Citation>ChemMedChem. 2015 Jul;10(7):1163-73</Citation><ArticleIdList><ArticleId IdType="pubmed">26083237</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 29;395(10225):689-697</Citation><ArticleIdList><ArticleId IdType="pubmed">32014114</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2020 May 5;172(9):629-632</Citation><ArticleIdList><ArticleId IdType="pubmed">32163542</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2016 Feb;22(2):126-7</Citation><ArticleIdList><ArticleId IdType="pubmed">26845404</ArticleId></ArticleIdList></Reference><Reference><Citation>Shock. 2010 Jan;33(1):14-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19487982</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2004 Mar 5;303(5663):1532-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15001782</ArticleId></ArticleIdList></Reference><Reference><Citation>Haematologica. 2017 Feb;102(2):e65-e68</Citation><ArticleIdList><ArticleId IdType="pubmed">27742769</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Resusc. 2020 Apr 15;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32294809</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomed Res Int. 2017;2017:8272504</Citation><ArticleIdList><ArticleId IdType="pubmed">29387725</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2020 May 1;130(5):2202-2205</Citation><ArticleIdList><ArticleId IdType="pubmed">32217834</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2016 Jan;238(1):85-97</Citation><ArticleIdList><ArticleId IdType="pubmed">26383585</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Today. 2010 May;15(9-10):396-405</Citation><ArticleIdList><ArticleId IdType="pubmed">20223295</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2016 Oct;4(10):797-806</Citation><ArticleIdList><ArticleId IdType="pubmed">27574788</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Feb 7;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2020 May 19;52(5):856-871.e8</Citation><ArticleIdList><ArticleId IdType="pubmed">32289253</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975</Citation><ArticleIdList><ArticleId IdType="pubmed">32350134</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2014 May;20(5):511-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24784231</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2018 Jan 17;217(3):428-437</Citation><ArticleIdList><ArticleId IdType="pubmed">29325098</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2016 May 5;127(18):2173-81</Citation><ArticleIdList><ArticleId IdType="pubmed">27002116</ArticleId></ArticleIdList></Reference><Reference><Citation>Anesthesiology. 2015 Apr;122(4):864-75</Citation><ArticleIdList><ArticleId IdType="pubmed">25665049</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2019 Sep 17;51(3):443-450.e4</Citation><ArticleIdList><ArticleId IdType="pubmed">31422870</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatr Int. 2011 Oct;53(5):669-671</Citation><ArticleIdList><ArticleId IdType="pubmed">21261785</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:145-147</Citation><ArticleIdList><ArticleId IdType="pubmed">32291094</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2018 Apr 12;51(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">29449427</ArticleId></ArticleIdList></Reference><Reference><Citation>JCI Insight. 2020 Jun 4;5(11):</Citation><ArticleIdList><ArticleId IdType="pubmed">32329756</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 2018 Aug 15;833:432-440</Citation><ArticleIdList><ArticleId IdType="pubmed">29981294</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 2010 Sep 1;641(2-3):220-5</Citation><ArticleIdList><ArticleId IdType="pubmed">20542026</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Apr 16;382(16):1564-1567</Citation><ArticleIdList><ArticleId IdType="pubmed">32182409</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Allergy. 2012 Jul;42(7):1097-103</Citation><ArticleIdList><ArticleId IdType="pubmed">22702508</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Jul;92(7):868-882</Citation><ArticleIdList><ArticleId IdType="pubmed">32329522</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1033-1034</Citation><ArticleIdList><ArticleId IdType="pubmed">32192578</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation><ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2009 Nov;15(11):1318-21</Citation><ArticleIdList><ArticleId IdType="pubmed">19855397</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2019 Dec;106(6):1359-1366</Citation><ArticleIdList><ArticleId IdType="pubmed">31478257</ArticleId></ArticleIdList></Reference><Reference><Citation>Intern Med. 2010;49(5):427-30</Citation><ArticleIdList><ArticleId IdType="pubmed">20190477</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2018 Jun;19(6):625-635</Citation><ArticleIdList><ArticleId IdType="pubmed">29777224</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurochem. 2014 Aug;130(4):555-62</Citation><ArticleIdList><ArticleId IdType="pubmed">24762056</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2010 Mar;35(3):564-70</Citation><ArticleIdList><ArticleId IdType="pubmed">19643947</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2020 May 15;201(10):1294-1297</Citation><ArticleIdList><ArticleId IdType="pubmed">32200645</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Clin Pharmacol Ther. 2013 Apr;51(4):288-304</Citation><ArticleIdList><ArticleId IdType="pubmed">23391369</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2020 Jun 1;217(6):</Citation><ArticleIdList><ArticleId IdType="pubmed">32302401</ArticleId></ArticleIdList></Reference><Reference><Citation>Open Forum Infect Dis. 2019 Apr 22;6(4):ofz072</Citation><ArticleIdList><ArticleId IdType="pubmed">31024969</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2008 Oct 1;198(7):962-70</Citation><ArticleIdList><ArticleId IdType="pubmed">18710327</ArticleId></ArticleIdList></Reference><Reference><Citation>Thorax. 2018 Jun;73(6):578-580</Citation><ArticleIdList><ArticleId IdType="pubmed">28780505</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2017 Apr 18;8:14780</Citation><ArticleIdList><ArticleId IdType="pubmed">28416795</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Singapour</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Bavière</li><li>District de Moyenne-Franconie</li><li>Grand Est</li><li>Oklahoma</li><li>Tennessee</li></region><settlement><li>Erlangen</li><li>Strasbourg</li></settlement><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="États-Unis"><region name="Oklahoma"><name sortKey="Narasaraju, Teluguakula" sort="Narasaraju, Teluguakula" uniqKey="Narasaraju T" first="Teluguakula" last="Narasaraju">Teluguakula Narasaraju</name></region><name sortKey="Radic, Marko" sort="Radic, Marko" uniqKey="Radic M" first="Marko" last="Radic">Marko Radic</name></country><country name="Australie"><noRegion><name sortKey="Tang, Benjamin M" sort="Tang, Benjamin M" uniqKey="Tang B" first="Benjamin M" last="Tang">Benjamin M. Tang</name></noRegion></country><country name="Allemagne"><region name="Bavière"><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name></region></country><country name="France"><noRegion><name sortKey="Muller, Sylviane" sort="Muller, Sylviane" uniqKey="Muller S" first="Sylviane" last="Muller">Sylviane Muller</name></noRegion><name sortKey="Muller, Sylviane" sort="Muller, Sylviane" uniqKey="Muller S" first="Sylviane" last="Muller">Sylviane Muller</name></country><country name="Singapour"><noRegion><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32581816
|texte= Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32581816" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |